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Filters for Globular Protein Evaluation


Hydrophobicity Ratio

The hydrophobicity ratio, ΦH is defined here as the ratio of loss in accessible surface area (ASA) per atom of non-polar atoms to the loss in accessible surface area (ASA) per atom of the polar atoms,

H)  = Loss in ASA per atom of non-polar atoms
         
           Loss in ASA per atom of polar atoms

For ~1000 protein dataset, the ratio F H was calculated and a graph between the hydrophobicity ratio and frequency was plotted (Fig.). The hydrophobicity ratio varies from 1.0-1.9 in conformity with expectations. We have selected the range from 1.2-1.6, which lies within the 95% confidence limits as a filter. HOW TO USE TOOL


Generate a structure with customized dihedral

Step1 - Input Protein Sequence (Single letter Code) *      
Step2 - Select Secondary Structure *                             


Range -
Step3                                                                           
Step4                                                                          
Enter PDB Name *




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