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Filters for Globular Protein Evaluation
Radius of Gyration

Radius of gyration describes the overall spread of the molecule and is defined as the root mean square distance of the collection of atoms from their common centre of gravity. Radius of gyration analysis for a dataset of ~1000 globular proteins from PDB database is performed and the values are plotted against N3/5(N is the no. of Amino Acids) (fig).

Rg = 0.395*N3/5 + 7.257

This filter can be employed to evaluate the value of radius of gyration for a given protein and to find out whether the protein follows the above equation or not.

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