Lipinski Rule of Five

Lipinski rule of 5 helps in distinguishing between drug like and non drug like molecules. It predicts high probability of success or failure due to drug likeness for molecules complying with 2 or more of the following rules

  • Molecular mass less than 500 Dalton
  • High lipophilicity (expressed as LogP less than 5)
  • Less than 5 hydrogen bond donors
  • Less than 10 hydrogen bond acceptors
  • Molar refractivity should be between 40-130

These filters help in early preclinical development and could help avoid costly late-stage preclinical and clinical failures .To draw a chemical structure Click Here and follow the instructions given.

Lipinski Drug Filters
Displays Lipinski Drug Filters
Upload the file in the given format[Sample File]:

How to Use the Tool


  1. The input File should be a pdb file (See Sample File to see the format)
  2. The input file name should not contain whitespace(s).
  3. Browse and Upload the file.
  4. Click on Submit.
  5. If the results were not showing, please recheck you input file format and submit it again.


  1. To draw a chemical structure Click Here .
  2. Follow the instructions given.
  3. Browse and Upload the file.
  4. Click on Submit.

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