Lipinski Rule of Five
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Lipinski Rule of Five
Lipinski rule of 5 helps in distinguishing between drug like and non drug like molecules. It predicts high probability of success or failure due to drug likeness for molecules complying with 2 or more of the following rules

  • Molecular mass less than 500 Dalton
  • High lipophilicity (expressed as LogP less than 5)
  • Less than 5 hydrogen bond donors
  • Less than 10 hydrogen bond acceptors
  • Molar refractivity should be between 40-130


  • These filters help in early preclinical development and could help avoid costly late-stage preclinical and clinical failures .To draw a chemical structure Click Here and follow the instructions given.

    Step 1: Input Drug File.

               Input PDB file


    Step 2 : Input pH Value

    pH Value     [Value ranges from 0.0 to 14.0]


    Step 3: Click on 'Submit' to submit your job



    How to Use the Tool

    OPTION 1:-
  • The input File should be in the following formats[*.pdb, *.mol,*.mol2,*.xyz,*.sdf,*.smi]
  • The input file name should not contain whitespace(s).
  • Browse and Upload the file.
  • Click on Submit.
  • If the results were not showing, please recheck you input file format and submit it again.
  • OPTION 2:-
  • To draw a chemical structure Click Here .
  • Follow the instructions given.
  • Browse and Upload the file.
  • Click on Submit.
  • For Feedback/Queries/Reportings bugs/Suggestions mail us at : abhilash@scfbio-iitd.res.in


    References:
    Cite as:
    Lipinski CA (December 2004). "Lead- and drug-like compounds: the rule-of-five revolution". Drug Discovery Today: Technologies 1 (4): 337–341. doi:10.1016/j.ddtec.2004.11.007
    B. Jayaram, Tanya Singh, Goutam Mukherjee, Abhinav Mathur, Shashank Shekhar, and Vandana Shekhar, "Sanjeevini: a freely accessible web-server for target directed lead molecule discovery", BMC Bioinformatics, 2012, 13, S7. http://www.biomedcentral.com/1471-2105/13/S17/S7

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